* 출처 : http://nownews.seoul.co.kr/news/newsView.php?id=20120624601001
“살 찌는게 싫으면 사과 통째로 드세요”
나우뉴스 | 입력: 2012.06.24 ㅣ 수정 2012.06.27 09:26
사과껍질 속에 비만을 억제하는 성분이 있다는 연구결과가 발표돼 관심을 끌고있다.
사이언스 데일리의 최근 보도에 따르면 미국 아이오와대학 당뇨병 연구센터의 크리스토퍼 애담스 박사 등 연구진은 사과껍질에 들어있는 우르솔산(ursolic acid)이 에너지를 연소해 인간의 근육과 갈색지방을 증가시켜 비만을 억제한다는 사실을 밝혀내 지난 20일 과학전문지’PLoS onE’ 에 발표했다.
연구진은 비만 쥐들에게 우르솔산을 먹인 결과 놀랄정도로 칼로리를 연소시키는 갈색지방과 근육이 증가하면서 체중은 덜 늘고 혈당도 정상을 유지하는 등 비만과 대사증후군이 현저히 줄어들었다고 밝혔다.
갈색지방은 최근까지는 영유아기에만 존재하고 유년기에는 사라지는 것으로 알려졌으나 영상기술의 발달로 어른들도 목과 어깨 사이에 매우 적은 양이지만 존재하는 것으로 밝혀졌다.
애담스 박사는“갈색지방은 유용하고 사람들은 그것을 증가시키는 방법을 알아내려고 합니다. 하지만 지금 중요한 건 우르솔산이 비만환자들을 어떻게 도울 수 있는지 확인하는 것입니다”고 강조했다.
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아래는 위 기사에 나온 Science Daily 의 기사 전문.
내가 우리나라의 이런 류의 기사 - 건강이나 이런 거 관련 - 를 볼 때 눈여겨 보질 않았던 것인가??...
우리나라 기사에서 보기 어려운 모습을 하나 보게 되었다.
자신들의 기사 출처(story source)를 기재해 놓고, 참고로 한 논문의 출처(journal reference) 링크도 기사 아래에 기재하고 있다는 점이다.
* 출처 : http://www.sciencedaily.com/releases/2012/06/120620212855.htm
Apple Peel Compound Boosts Brown Fat, Reduces Obesity in Mice
ScienceDaily (June 20, 2012) — Obesity and its associated problems such as diabetes and fatty liver disease are increasingly common global health concerns. A new study by University of Iowa researchers shows that a natural substance found in apple peel can partially protect mice from obesity and some of its harmful effects.
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The findings suggest that the substance known as ursolic acid reduces obesity and its associated health problems by increasing the amount of muscle and brown fat, two tissues recognized for their calorie-burning properties.
The study, which was published June 20 in the journal PLoS onE, was led by Christopher Adams, M.D., Ph.D., UI associate professor of internal medicine and a Faculty Scholar at the Fraternal Order of Eagles Diabetes Research Center at the UI.
"From previous work, we knew that ursolic acid increases muscle mass and strength in healthy mice, which is important because it might suggest a potential therapy for muscle wasting," Adams says. "In this study, we tested ursolic acid in mice on a high-fat diet -- a mouse model of obesity and metabolic syndrome. once again, ursolic acid increased skeletal muscle. Interestingly, it also reduced obesity, pre-diabetes and fatty liver disease.
"Since muscle is very good at burning calories, the increased muscle in ursolic acid-treated mice may be sufficient to explain how ursolic acid reduces obesity. However, we were surprised to find that ursolic acid also increased brown fat, a fantastic calorie burner. This increase in brown fat may also help protect against obesity."
Until quite recently, researchers believed that only infants had brown fat, which then disappeared during childhood. However, improved imaging techniques have shown that adults do retain a very small amount of the substance mostly in the neck and between the shoulder blades. Some studies have linked increased levels of brown fat with lower levels of obesity and healthier levels of blood sugar and blood lipid, leading to the suggestion that brown fat may be helpful in preventing obesity and diabetes.
The UI team, which also included Steven Kunkel, Christopher Elmore, Kale Bongers, Scott Ebert, Daniel Fox, Michael Dyle, and Steven Bullard, studied mice on a high-fat diet over a period of several weeks. Half of the animals also received ursolic acid in their high-fat food. Interestingly, mice whose diet included ursolic acid actually ate more food than mice not getting the supplement, and there was no difference in activity between the two groups. Despite this, the ursolic acid-treated mice gained less weight and their blood sugar level remained near normal. Ursolic acid-treated mice also failed to develop obesity-related fatty liver disease, a common and currently untreatable condition that affects about one in five American adults.
Further study showed that ursolic acid consumption increased skeletal muscle, increasing the animals' strength and endurance, and also boosted the amount of brown fat. Because both muscle and brown fat burn calories, the researchers investigated energy expenditure in the mice and showed that ursolic acid-fed mice burned more calories than mice that didn't get the supplement.
"Our study suggests that ursolic acid increases skeletal muscle and brown fat leading to increased calorie burning, which in turn protects against diet-induced obesity, pre-diabetes and fatty liver disease," Adams says. "Brown fat is beneficial and people are trying to figure out ways to increase it. At this point, we don't know how ursolic acid increases brown fat, or if it increases brown fat in healthy mice. And, most importantly, we don't know if ursolic acid will benefit people. Our next step is to determine if ursolic acid can help patients."
The research was supported by funding from the Fraternal Order of Eagles Diabetes Research Center at the University of Iowa, the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (grant 5R01AR059115-03), the Department of Veterans Affairs, and the University of Iowa Research Foundation.
Story Source:
The above story is reprinted from materials provided by University of Iowa, via Newswise.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Kunkel SD, Elmore CJ, Bongers KS, Ebert SM, Fox DK, et al. Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease.. PLoS onE, 2012 DOI: 10.1371/journal.pone.0039332
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff
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